The six-day event will kick-off with an entire weekend dedicated to educating and entertaining families.
From a science sleepover in a museum and science superheroes to freaky food of the future and walking on custard, there will be something to capture the imagination and interest of all.
Events will take place across the city at venues including the Newcastle and Northumbria Universities, the Centre for Life, the Great North Museum: Hancock, the City Library and the Discovery Museum.
Newcastle University and Northumbria University will throw open the doors to give visitors a behind-the-scenes look at some of the science they are working on. There will be lots to learn about – everything from bacteria and poisons to electronics and ageing, and even why our fingers go wrinkly in the bath!